Mary Zutter
Faculty Member
Last active: 4/26/2016

Proteases, extracellular matrix, and cancer: a workshop of the path B study section.

DeClerck YA, Mercurio AM, Stack MS, Chapman HA, Zutter MM, Muschel RJ, Raz A, Matrisian LM, Sloane BF, Noel A, Hendrix MJ, Coussens L, Padarathsingh M
Am J Pathol. 2004 164 (4): 1131-9

PMID: 15039201 · PMCID: PMC1615345 · DOI:10.1016/S0002-9440(10)63200-2

The role of the extracellular matrix (ECM) in the tumor microenvironment is not limited to being a barrier against tumor invasion. The ECM is a reservoir of cell binding proteins and growth factors that affect tumor cell behavior. It is also substantially modified by proteases produced by tumor cells or stroma cells. As a result of the activity of these proteases, cell-cell and cell-ECM interactions are altered, new biologically active ECM molecules are generated, and the bioavailability and activity of many growth factors, growth factor receptors, and cytokines are modified. ECM-degrading proteases also play a critical role in angiogenesis, where they can act as positive as well as negative regulators of endothelial cell proliferation and vascular morphogenesis. This review article summarizes some of the most relevant findings made over the recent years that were discussed at a workshop organized by the Path B Study Section of the National Institutes of Health in October 2002.

MeSH Terms (6)

Animals Cell Communication Endopeptidases Extracellular Matrix Humans Neoplasms

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