Mary Zutter
Faculty Member
Last active: 4/26/2016

Aberrant expression of T-cell-associated antigens on B-cell non-Hodgkin lymphomas.

Kaleem Z, White G, Zutter MM
Am J Clin Pathol. 2001 115 (3): 396-403

PMID: 11242796 · DOI:10.1309/v8yg-8pp4-b4te-9x6j

We describe 9 well-characterized cases of B-cell non-Hodgkin lymphoma (NHL) that showed aberrant expression of T-cell-associated antigens by 2-color flow cytometry. Cases were as follows: chronic lymphocytic leukemia/small lymphocytic lymphoma, 4; follicle center cell lymphoma, 2; mantle cell lymphoma, 1; and diffuse large B-cell lymphoma, 2. CD2 was the most commonly expressed antigen (5 cases). CD8 and CD7 were identified in 2 cases each, including 1 case that expressed both CD7 and CD4. The disease course and response to treatment were compatible with the type and stage of lymphoma. No unusually aggressive behavior was noted in any case. A control group of 59 cases of benign lymph nodes analyzed during the same period showed no aberrant expression of T-cell-associated antigens; thus, such expression is not a feature of benign lymphoid proliferations. Study of these B-cell lymphomas may prove invaluable to study aberrant activation of silent or repressed T-cell differentiation genes. CD2-expressing B-cell NHLs may represent clonal expansion of CD2+ B lymphocytes that normally constitute a small fraction of peripheral B lymphocytes and should not be confused with composite B- and T-cell lymphomas. Unless aggressive behavior is noted consistently, no aggressive treatment is justified.

MeSH Terms (19)

Aged Aged, 80 and over Antigens, CD Antigens, CD7 B-Lymphocytes CD2 Antigens CD4 Antigens CD8 Antigens Female Flow Cytometry Humans Leukemia, Lymphocytic, Chronic, B-Cell Lymphoma, B-Cell Lymphoma, Follicular Lymphoma, Large B-Cell, Diffuse Lymphoma, Mantle-Cell Male Middle Aged T-Lymphocytes

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