Mary Zutter
Faculty Member
Last active: 4/26/2016

Mast cell-mediated inflammatory responses require the alpha 2 beta 1 integrin.

Edelson BT, Li Z, Pappan LK, Zutter MM
Blood. 2004 103 (6): 2214-20

PMID: 14645004 · DOI:10.1182/blood-2003-08-2978

Although the alpha 2 beta 1 integrin is widely expressed and has been extensively studied, it has not been previously implicated in mast cell biology. We observed that alpha 2 integrin subunit-deficient mice exhibited markedly diminished neutrophil and interleukin-6 responses during Listeria monocytogenes- and zymosan-induced peritonitis. Since exudative neutrophils of wild-type mice expressed little alpha 2 beta 1 integrin, it seemed unlikely that this integrin mediated neutrophil migration directly. Here, we demonstrate constitutive alpha 2 beta 1 integrin expression on peritoneal mast cells. Although alpha 2-null mice contain normal numbers of peritoneal mast cells, these alpha 2-null cells do not support in vivo mast cell-dependent inflammatory responses. We conclude that alpha 2 beta 1 integrin provides a costimulatory function required for mast cell activation and cytokine production in response to infection.

MeSH Terms (11)

Animals Cell Degranulation Disease Models, Animal Integrin alpha2 Integrin alpha2beta1 Listeriosis Mast Cells Mice Mice, Inbred C57BL Mice, Mutant Strains Peritoneal Cavity

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