John Jeffrey Carr
Professor of Radiology, Biomedical Informatics and Cardiovascular Medicine
Last active: 9/11/2017

Coffee consumption and calcified atherosclerotic plaques in the coronary arteries: The NHLBI Family Heart Study.

Patel YR, Gadiraju TV, Ellison RC, Hunt SC, Carr JJ, Heiss G, Arnett DK, Pankow JS, Gaziano JM, Djoussé L
Clin Nutr ESPEN. 2017 17: 18-21

PMID: 28361742 · PMCID: PMC5501720 · DOI:10.1016/j.clnesp.2016.12.003

BACKGROUND & AIMS - While a recent meta-analysis of prospective studies reported that coffee consumption is associated with a lower risk of cardiovascular disease mortality, limited and inconsistent data are available on the relation of coffee intake with subclinical disease. Thus, the aim of the present study was to see the association of coffee consumption with the prevalence of atherosclerotic plaque in the coronary arteries in NHLBI Family Heart Study.

METHODS - In a cross-sectional design, we studied 1929 participants of the NHLBI Family Heart Study without known coronary heart disease. Coffee consumption was assessed by a semi-quantitative food frequency questionnaire and coronary-artery calcium (CAC) was measured by cardiac computed tomography. We defined prevalent CAC as an Agatston score of ≥100 and used generalized estimating equations to calculate prevalence ratios of CAC as well as a sensitivity analysis at a range of cutpoints for CAC.

RESULTS - Mean age was 56.7 years and 59% of the study subjects were female. In adjusted analysis for age, sex, BMI, smoking, alcohol, physical activity, field center, and energy intake, prevalence ratio (95% CI) for CAC was 1.0 (reference), 0.92 (0.57-1.49), 1.34 (0.86-2.08), 1.30 (0.84-2.02), and 0.99 (0.60-1.64) for coffee consumption of almost never, <1/day, 1/day, 2-3/day, and ≥4 cups/day, respectively. In a sensitivity analysis, there was no evidence of association between coffee consumption and prevalent CAC when CAC cut points of 0, 50, 150, 200, and 300 were used.

CONCLUSIONS - These data do not provide evidence for an association between coffee consumption and prevalent CAC in adult men and women.

Copyright © 2016 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.

MeSH Terms (17)

Adult Aged Coffee Computed Tomography Angiography Coronary Angiography Coronary Artery Disease Coronary Vessels Cross-Sectional Studies Female Humans Male Middle Aged Plaque, Atherosclerotic Prevalence Risk Factors United States Vascular Calcification

Connections (1)

This publication is referenced by other Labnodes entities:

Links