John Jeffrey Carr
Professor of Radiology, Biomedical Informatics and Cardiovascular Medicine
Last active: 9/11/2017

Adiposity is inversely associated with hippocampal volume in African Americans and European Americans with diabetes.

Hsu FC, Yuan M, Bowden DW, Xu J, Smith SC, Wagenknecht LE, Langefeld CD, Divers J, Register TC, Carr JJ, Williamson JD, Sink KM, Maldjian JA, Freedman BI
J Diabetes Complications. 2016 30 (8): 1506-1512

PMID: 27615667 · PMCID: PMC5050135 · DOI:10.1016/j.jdiacomp.2016.08.012

AIMS - To assess associations between body mass index (BMI), waist circumference (WC), and computed tomography-determined volumes of pericardial, visceral, and subcutaneous adipose tissue with magnetic resonance imaging-(MRI) based cerebral structure and cognitive performance in individuals with type 2 diabetes (T2D).

METHODS - This study was performed in 348 African Americans (AAs) and 256 European Americans (EAs) with T2D. Associations between adiposity measures with cerebral volumes of white matter (WMV), gray matter (GMV), white matter lesions, hippocampal GMV, and hippocampal WMV, cognitive performance and depression were examined using marginal models incorporating generalized estimating equations. All models were adjusted for age, sex, education, smoking, HbA1c, hypertension, statins, cardiovascular disease, MRI scanner (MRI outcomes only), and time between scans; some neuroimaging measures were additionally adjusted for intracranial volume.

RESULTS - Participants were 59.9% female with mean (SD) age 57.7(9.3)years, diabetes duration 9.6(6.8)years, and HbA1c 7.8(1.9)%. In AAs, inverse associations were detected between hippocampal GMV and both BMI (β [95% CI]-0.18 [-0.30, -0.07], P=0.0018) and WC (-0.23 [-0.35, -0.12], P=0.0001). In the full bi-ethnic sample, inverse associations were detected between hippocampal WMV and WC (P≤0.0001). Positive relationships were observed between BMI (P=0.0007) and WC (P<0.0001) with depression in EAs.

CONCLUSIONS - In patients with T2D, adiposity is inversely associated with hippocampal gray and white matter volumes.

Copyright © 2016 Elsevier Inc. All rights reserved.

MeSH Terms (19)

Adipose Tissue Adiposity African Americans Aged Body Mass Index Diabetes Mellitus, Type 2 European Continental Ancestry Group Female Gray Matter Hippocampus Humans Magnetic Resonance Imaging Male Middle Aged Organ Size Tomography, X-Ray Computed United States Waist Circumference White Matter

Connections (1)

This publication is referenced by other Labnodes entities:

Links