John Jeffrey Carr
Professor of Radiology, Biomedical Informatics and Cardiovascular Medicine
Last active: 1/10/2020

Intermuscular Adipose Tissue and Subclinical Coronary Artery Calcification in Midlife: The CARDIA Study (Coronary Artery Risk Development in Young Adults).

Terry JG, Shay CM, Schreiner PJ, Jacobs DR, Sanchez OA, Reis JP, Goff DC, Gidding SS, Steffen LM, Carr JJ
Arterioscler Thromb Vasc Biol. 2017 37 (12): 2370-2378

PMID: 29025708 · PMCID: PMC5699947 · DOI:10.1161/ATVBAHA.117.309633

OBJECTIVE - Excess deposition of fat within and around vital organs and nonadipose tissues is hypothesized to contribute to cardiovascular disease (CVD) risk. We evaluated the association of abdominal intermuscular adipose tissue (IMAT) volume with coronary artery calcification in the CARDIA study (Coronary Artery Risk Development in Young Adults) participants.

APPROACH AND RESULTS - We measured IMAT in the abdominal muscles, visceral adipose tissue and pericardial adipose tissue, and coronary artery calcification using computed tomography in 3051 CARDIA participants (56% women) at the CARDIA year 25 examination (2010-2011). Mean IMAT volume and mean IMAT/total muscle volume (IMAT normalized for muscle size) were calculated in a 10-mm block of slices centered at L3-L4. Multivariable analyses included potential confounders and traditional cardiovascular disease risk factors. Compared with the lowest quartile, the upper quartile of abdominal IMAT volume was associated with higher coronary artery calcification prevalence (odds ratio [95% confidence interval], 1.6 [1.2-2.1]) after adjusting for cardiovascular disease risk factors. Results were similar for highest versus lowest quartile of IMAT normalized to total muscle volume (odds ratio [95% confidence interval], 1.5 [1.1-2.0]). Significant associations of higher IMAT and normalized IMAT with coronary artery calcification prevalence persisted when body mass index, visceral adipose tissue, or pericardial adipose tissue were added to the models.

CONCLUSIONS - In a large, community-based, cross-sectional study, we found that higher abdominal skeletal muscle adipose tissue volume was associated with subclinical atherosclerosis independent of traditional cardiovascular disease risk factors and other adipose depots.

© 2017 American Heart Association, Inc.

MeSH Terms (25)

Abdominal Muscles Adiposity Adolescent Adult Age Factors Asymptomatic Diseases Computed Tomography Angiography Coronary Angiography Coronary Artery Disease Cross-Sectional Studies Female Humans Intra-Abdominal Fat Logistic Models Male Middle Aged Multidetector Computed Tomography Multivariate Analysis Odds Ratio Pericardium Prevalence Risk Factors United States Vascular Calcification Young Adult

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