Unique mitochondrial DNA in highly inbred feral cattle.

Hudson G, Wilson I, Payne BI, Elson J, Samuels DC, Santibanez-Korev M, Hall SJ, Chinnery PF
Mitochondrion. 2012 12 (4): 438-40

PMID: 22609322 · PMCID: PMC3485552 · DOI:10.1016/j.mito.2012.05.003

The Chillingham herd of wild Northumbrian cattle remains viable despite over 300 years of in-breeding and a near-homozygous nuclear genome. Here we report the complete mitochondrial DNA sequence using ultra-deep next generation sequencing. Random population sampling of ~10% of the extant herd identified a single mtDNA haplotype harbouring a unique bovine variant present in all other higher mammals (m.11789C/Y421H) which may contribute to their survival.

Copyright © 2012 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

MeSH Terms (9)

Animals Animals, Inbred Strains Cattle Cluster Analysis DNA, Mitochondrial Genome, Mitochondrial Haplotypes High-Throughput Nucleotide Sequencing Phylogeny

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