Dietary Manganese Promotes Staphylococcal Infection of the Heart.

Juttukonda LJ, Berends ETM, Zackular JP, Moore JL, Stier MT, Zhang Y, Schmitz JE, Beavers WN, Wijers CD, Gilston BA, Kehl-Fie TE, Atkinson J, Washington MK, Peebles RS, Chazin WJ, Torres VJ, Caprioli RM, Skaar EP
Cell Host Microbe. 2017 22 (4): 531-542.e8

PMID: 28943329 · PMCID: PMC5638708 · DOI:10.1016/j.chom.2017.08.009

Diet, and specifically dietary metals, can modify the risk of infection. However, the mechanisms by which manganese (Mn), a common dietary supplement, alters infection remain unexplored. We report that dietary Mn levels dictate the outcome of systemic infections caused by Staphylococcus aureus, a leading cause of bacterial endocarditis. Mice fed a high Mn diet display alterations in Mn levels and localization within infected tissues, and S. aureus virulence and infection of the heart are enhanced. Although the canonical mammalian Mn-sequestering protein calprotectin surrounds staphylococcal heart abscesses, calprotectin is not released into the abscess nidus and does not limit Mn in this organ. Consequently, excess Mn is bioavailable to S. aureus in the heart. Bioavailable Mn is utilized by S. aureus to detoxify reactive oxygen species and protect against neutrophil killing, enhancing fitness within the heart. Therefore, a single dietary modification overwhelms vital host antimicrobial strategies, leading to fatal staphylococcal infection.

Copyright © 2017 Elsevier Inc. All rights reserved.

MeSH Terms (17)

Abscess Animals Diet Disease Models, Animal Endocarditis, Bacterial Heart Humans Leukocyte L1 Antigen Complex Liver Manganese Mice Mice, Congenic Mice, Inbred C57BL Neutrophils Reactive Oxygen Species Staphylococcal Infections Staphylococcus aureus

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