XPA: A key scaffold for human nucleotide excision repair.

Sugitani N, Sivley RM, Perry KE, Capra JA, Chazin WJ
DNA Repair (Amst). 2016 44: 123-135

PMID: 27247238 · PMCID: PMC4958585 · DOI:10.1016/j.dnarep.2016.05.018

Nucleotide excision repair (NER) is essential for removing many types of DNA lesions from the genome, yet the mechanisms of NER in humans remain poorly understood. This review summarizes our current understanding of the structure, biochemistry, interaction partners, mechanisms, and disease-associated mutations of one of the critical NER proteins, XPA.

Copyright © 2016 Elsevier B.V. All rights reserved.

MeSH Terms (15)

Amino Acid Sequence Animals DNA DNA Damage DNA Repair Humans Models, Molecular Mutation Protein Binding Protein Domains Protein Interaction Mapping Protein Structure, Secondary Severity of Illness Index Xeroderma Pigmentosum Xeroderma Pigmentosum Group A Protein

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