SR-BI: A Multifunctional Receptor in Cholesterol Homeostasis and Atherosclerosis.

Linton MF, Tao H, Linton EF, Yancey PG
Trends Endocrinol Metab. 2017 28 (6): 461-472

PMID: 28259375 · PMCID: PMC5438771 · DOI:10.1016/j.tem.2017.02.001

The HDL receptor scavenger receptor class B type I (SR-BI) plays crucial roles in cholesterol homeostasis, lipoprotein metabolism, and atherosclerosis. Hepatic SR-BI mediates reverse cholesterol transport (RCT) by the uptake of HDL cholesterol for routing to the bile. Through the selective uptake of HDL lipids, hepatic SR-BI modulates HDL composition and preserves HDL's atheroprotective functions of mediating cholesterol efflux and minimizing inflammation and oxidation. Macrophage and endothelial cell SR-BI inhibits the development of atherosclerosis by mediating cholesterol trafficking to minimize atherosclerotic lesion foam cell formation. SR-BI signaling also helps limit inflammation and cell death and mediates efferocytosis of apoptotic cells in atherosclerotic lesions thereby preventing vulnerable plaque formation. SR-BI is emerging as a multifunctional therapeutic target to reduce atherosclerosis development.

Copyright © 2017 Elsevier Ltd. All rights reserved.

MeSH Terms (7)

Animals Atherosclerosis Biological Transport Cholesterol Endothelial Cells Humans Macrophages

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