Uric acid correlates to oxidation and inflammation in opposite directions in women.

Wu SH, Shu XO, Milne G, Xiang YB, Zhang X, Cai Q, Fazio S, Linton MF, Chen H, Purdue M, Rothman N, Gao YT, Zheng W, Yang G
Biomarkers. 2015 20 (4): 225-31

PMID: 26301880 · PMCID: PMC4989504 · DOI:10.3109/1354750X.2015.1068852

OBJECTIVE - To evaluate the association of uric acid (UA) levels with a panel of markers of oxidative stress and inflammation.

METHODS - Plasma UA levels, along with a panel of oxidative stress and inflammatory markers, were measured in 755 Chinese women.

RESULTS - Plasma UA levels were inversely associated with urinary levels of the oxidative stress marker F2-isoprostanes and positively correlated to levels of inflammatory markers, such as C-reactive protein and some proinflammatory cytokines (tumor necrosis factor-α and interleukin-6) in blood as well as prostaglandin E2 metabolites in urine.

CONCLUSIONS - Plasma UA levels correlate to oxidation and inflammation biomarkers in opposite directions in women.

MeSH Terms (17)

Aged Biomarkers C-Reactive Protein Case-Control Studies Chromatography, Liquid F2-Isoprostanes Female Gas Chromatography-Mass Spectrometry Humans Inflammation Inflammation Mediators Interleukin-6 Middle Aged Oxidation-Reduction Tandem Mass Spectrometry Tumor Necrosis Factor-alpha Uric Acid

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