Cutting edge: Guillain-Barre syndrome-associated IgG responses to gangliosides are generated independently of CD1 function in mice.

Matsumoto Y, Yuki N, Van Kaer L, Furukawa K, Hirata K, Sugita M
J Immunol. 2008 180 (1): 39-43

PMID: 18097001 · DOI:10.4049/jimmunol.180.1.39

CD1 molecules present a variety of microbial glycolipids and self-glycolipids to T cells, but their potential role in humoral responses to glycolipid Ags remains to be established. To address this issue directly, we used GM1/GD1a-deficient mice, which, upon immunization with heat-killed Campylobacter jejuni, develop Guillain-Barré syndrome-associated IgG Abs against the GM1/GD1a sugar chain epitopes of bacterial lipo-oligosaccharides (LOS). Our results showed that anti-ganglioside Abs of the IgG1, IgG2b, and IgG3 isotypes were produced in the absence of group 2 CD1 (CD1d) expression. Unlike mouse and human group 2 CD1 molecules that specifically bound LOS, none of the group 1 CD1 molecules (CD1a, CD1b, and CD1c in humans) were capable of interacting with LOS. Thus, these results indicate CD1-independent pathways for anti-ganglioside Ab production.

MeSH Terms (12)

Animals Antibodies Antibody Formation Antigens, CD1 Campylobacter jejuni G(M1) Ganglioside Gangliosides Guillain-Barre Syndrome Immunoglobulin G Lipopolysaccharides Mice Mice, Mutant Strains

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