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The hunt for iNKT cell antigens: alpha-galactosidase-deficient mice to the rescue?

Van Kaer L, Joyce S
Immunity. 2010 33 (2): 143-5

PMID: 20732635 · DOI:10.1016/j.immuni.2010.08.009

The endogenous lipids that control the functions of invariant natural killer T (iNKT) cells remain enigmatic. In this issue of Immunity, Darmoise et al. (2010) report that lysosomal alpha-galactosidase A destroys self-antigens recognized by iNKT cells.

Copyright 2010 Elsevier Inc. All rights reserved.

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