Impact of premature ovarian failure on mortality and morbidity among Chinese women.

Wu X, Cai H, Kallianpur A, Li H, Yang G, Gao J, Xiang YB, Ji BT, Yu-Tang , Zheng W, Shu XO
PLoS One. 2014 9 (3): e89597

PMID: 24603759 · PMCID: PMC3945971 · DOI:10.1371/journal.pone.0089597

OBJECTIVE - To evaluate associations of premature ovarian failure (POF) with mortality and morbidity in Asian populations.

METHODS - We identified 1,003 cases of POF among 36,402 postmenopausal women who participated in the Shanghai Women's Health Study, a population-based cohort study. Cox regression and logistic regression models were applied in data analysis.

RESULTS - After adjustment for potential confounding factors, we found that POF increased the risk of total and cancer-specific mortality (HR (95%CIs): 1.29 (1.08-1.54) and 1.38 (1.05-1.81), respectively). POF was also associated with high prevalence of autoimmune disease (OR (95%CI): 1.56 (1.04-2.35)) but decreased incidence of breast cancer (OR (95%CI): 0.59 (0.38-0.91)). Similar results were observed when hormone replacement therapy users were excluded from the analysis. POF is associated with high waist-to-hip ratio.

CONCLUSIONS - Our results suggest that women with POF experience increased mortality and that these women may benefit from heightened surveillance and appropriate interventions.

MeSH Terms (19)

Adult Aged Asian Continental Ancestry Group Autoimmune Diseases Breast Neoplasms China Cohort Studies Female Humans Incidence Logistic Models Middle Aged Morbidity Mortality Prevalence Primary Ovarian Insufficiency Proportional Hazards Models Waist-Hip Ratio Women's Health

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