Arrestin makes T cells stop and become active.

Gurevich VV, Gurevich EV
EMBO J. 2014 33 (6): 531-3

PMID: 24502974 · PMCID: PMC3989646 · DOI:10.1002/embj.201387724

T-cell activation requires signaling by T-cell receptors (TCRs) that bind antigen on the antigen-presenting cells (APCs) at the immunological synapse (IS). Sustained signaling requires continuous supply of new TCRs to the IS. In this issue of The EMBO Journal, Fernández-Arenas et al (2014) describe a novel role of β-arrestin-1 at the IS periphery: endocytosis of TCRs and chemokine CXCR4 receptors. Internalized TCRs are then delivered to the IS, where they engage antigen and support prolonged signaling, whereas CXCR4 internalization stops T-cell migration.

MeSH Terms (10)

Animals Arrestins beta-Arrestin 1 beta-Arrestins Gene Expression Regulation Humans Immunological Synapses Models, Immunological Receptors, Antigen, T-Cell Signal Transduction

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