The small heat shock protein, HSPB6, in muscle function and disease.

Dreiza CM, Komalavilas P, Furnish EJ, Flynn CR, Sheller MR, Smoke CC, Lopes LB, Brophy CM
Cell Stress Chaperones. 2010 15 (1): 1-11

PMID: 19568960 · PMCID: PMC2866971 · DOI:10.1007/s12192-009-0127-8

The small heat shock protein, HSPB6, is a 17-kDa protein that belongs to the small heat shock protein family. HSPB6 was identified in the mid-1990s when it was recognized as a by-product of the purification of HSPB1 and HSPB5. HSPB6 is highly and constitutively expressed in smooth, cardiac, and skeletal muscle and plays a role in muscle function. This review will focus on the physiologic and biochemical properties of HSPB6 in smooth, cardiac, and skeletal muscle; the putative mechanisms of action; and therapeutic implications.

MeSH Terms (14)

Amino Acid Sequence Animals Asthma HSP20 Heat-Shock Proteins Humans Hyperplasia Molecular Sequence Data Muscle, Skeletal Muscle, Smooth Myocardium Phosphopeptides Rats Signal Transduction Subarachnoid Hemorrhage

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