GLP-1: Molecular mechanisms and outcomes of a complex signaling system.

Smith NK, Hackett TA, Galli A, Flynn CR
Neurochem Int. 2019 128: 94-105

PMID: 31002893 · PMCID: PMC7081944 · DOI:10.1016/j.neuint.2019.04.010

Meal ingestion provokes the release of hormones and transmitters, which in turn regulate energy homeostasis and feeding behavior. One such hormone, glucagon-like peptide-1 (GLP-1), has received significant attention in the treatment of obesity and diabetes due to its potent incretin effect. In addition to the peripheral actions of GLP-1, this hormone is able to alter behavior through the modulation of multiple neural circuits. Recent work that focused on elucidating the mechanisms and outcomes of GLP-1 neuromodulation led to the discovery of an impressive array of GLP-1 actions. Here, we summarize the many levels at which the GLP-1 signal adapts to different systems, with the goal being to provide a background against which to guide future research.

Copyright © 2019. Published by Elsevier Ltd.

MeSH Terms (9)

Animals Brain Diabetes Mellitus, Type 2 Feeding Behavior Glucagon-Like Peptide 1 Humans Obesity Reward Signal Transduction

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