The effect of poisoning with Dithane M-45 on oxygen uptake and energy balance in adult rats.

Gawecki J, Urbanowicz M, Buchowski M, Borowicz T
Acta Physiol Pol. 1976 27 (2): 169-74

PMID: 1274609

Adult white rats were kept on natural diet containing various doses of Dithane M-45 (Mn and Zn ethylene-bisdithiocarbamate). Oxygen uptake (VO2), metabolic rate and energy balance were determined at intervals of several days. Oxygen uptake and metabolic rate were not significantly changed in animals receiving Dithane M-45 in concentrations of 5 and 50 ppm but they were significantly decreased in the animals kept on the diet containing the preparation in concentrations of 500, 2000 and 5000 ppm. The authors conclude that changes in body weight of animals after poisoning with Dithane M-45 are due, both to reduced supply and requirements for energy.

MeSH Terms (14)

Animals Body Weight Calorimetry Depression, Chemical Energy Metabolism Female Intestinal Absorption Maneb Oxygen Consumption Rats Thiocarbamates Thyroid Gland Time Factors Zineb

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