Mitochondrial haplogroups are associated with severity of diabetic retinopathy.

Estopinal CB, Chocron IM, Parks MB, Wade EA, Roberson RM, Burgess LG, Brantley MA, Samuels DC
Invest Ophthalmol Vis Sci. 2014 55 (9): 5589-95

PMID: 25118268 · PMCID: PMC4160073 · DOI:10.1167/iovs.14-15149

PURPOSE - To determine if specific mitochondrial haplogroups associate with nonproliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR).

METHODS - Deidentified medical records for Caucasian patients with diabetic retinopathy (DR; 153 NPDR and 138 PDR) were obtained from BioVU, Vanderbilt University's electronic, deidentified DNA databank. An independent cohort of Caucasian patients with DR (44 NPDR and 57 PDR) from the Vanderbilt Eye Institute (VEI) was used for validation. We tested for an association between mitochondrial haplogroups and PDR among patients with DR.

RESULTS - In the BioVU cohort, PDR frequency among Caucasian DR patients differed significantly by mitochondrial haplogroup (P = 0.027). Replication in the VEI cohort confirmed this association (P = 0.0064). In the combined cohort, patients from the common haplogroup H were more likely to have PDR (odds ratio [OR] = 2.0 [95% confidence interval (CI) = 1.3-3.0], P = 0.0012), while patients from haplogroup Uk were less likely to have PDR (OR = 0.5 [95% CI = 0.3-0.8], P = 0.0049). In logistic regression analyses, the addition of diabetes duration, hemoglobin A1c (HgbA1c) levels, and hypertension had no effect on the associations of haplogroups H and Uk with PDR.

CONCLUSIONS - In this study, DR patients from mitochondrial haplogroup H were more likely to have PDR, while DR patients from haplogroup Uk were less likely to have PDR. The association was independent of the major clinical variables affecting PDR. The mitochondrial haplogroups were as strong a risk factor for PDR as were elevated HgbA1c levels.

Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.

MeSH Terms (16)

Adult Aged Case-Control Studies Cohort Studies Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetic Retinopathy Female Genotype Glycated Hemoglobin A Haplotypes Humans Male Middle Aged Mitochondria Odds Ratio

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