Pharmacogenetics and age-related macular degeneration.

Schwartz SG, Brantley MA
J Ophthalmol. 2011 2011: 252549

PMID: 22046503 · PMCID: PMC3199209 · DOI:10.1155/2011/252549

Pharmacogenetics seeks to explain interpatient variability in response to medications by investigating genotype-phenotype correlations. There is a small but growing body of data regarding the pharmacogenetics of both nonexudative and exudative age-related macular degeneration. Most reported data concern polymorphisms in the complement factor H and age-related maculopathy susceptibility 2 genes. At this time, the data are not consistent and no definite conclusions may be drawn. As clinical trials data continue to accumulate, these relationships may become more apparent.

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