A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter.

Liou HC, Boothby MR, Finn PW, Davidon R, Nabavi N, Zeleznik-Le NJ, Ting JP, Glimcher LH
Science. 1990 247 (4950): 1581-4

PMID: 2321018 · DOI:10.1126/science.2321018

Several mutants derived from transformed human B cell lines are defective in expressing major histocompatibility complex (MHC) class II genes. The failure to express a class II gene in at least one such mutant line has been mapped to the MHC class II X box, a conserved transcriptional element in the promoter region. A complementary DNA encoding a DNA-binding protein (human X box binding protein, hXBP-1) whose target is the human DR alpha X box and the 3' flanking region has now been cloned. This complementary DNA encoded a protein with structural similarities to the c-jun proto-oncogene product, and its target sequence was closely related to the palindromic target sequence of c-jun. Mutation of the hXBP-1 DNA target sequence decreased DR alpha promoter activity in vivo. These studies suggest that the hXBP-1 protein acts as a transcription factor in B cells.

MeSH Terms (16)

Amino Acid Sequence B-Lymphocytes Base Sequence Binding Sites Cell Line, Transformed DNA DNA-Binding Proteins HLA-DR Antigens Humans Leucine Molecular Sequence Data Mutation Promoter Regions, Genetic Regulatory Factor X Transcription Factors Transcription Factors Transfection

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