TLR4 genotype and environmental LPS mediate RSV bronchiolitis through Th2 polarization.

Caballero MT, Serra ME, Acosta PL, Marzec J, Gibbons L, Salim M, Rodriguez A, Reynaldi A, Garcia A, Bado D, Buchholz UJ, Hijano DR, Coviello S, Newcomb D, Bellabarba M, Ferolla FM, Libster R, Berenstein A, Siniawaski S, Blumetti V, Echavarria M, Pinto L, Lawrence A, Ossorio MF, Grosman A, Mateu CG, Bayle C, Dericco A, Pellegrini M, Igarza I, Repetto HA, Grimaldi LA, Gudapati P, Polack NR, Althabe F, Shi M, Ferrero F, Bergel E, Stein RT, Peebles RS, Boothby M, Kleeberger SR, Polack FP
J Clin Invest. 2015 125 (2): 571-82

PMID: 25555213 · PMCID: PMC4319428 · DOI:10.1172/JCI75183

MeSH Terms (20)

Animals Bronchiolitis, Viral Disease Models, Animal Environmental Exposure Female GATA3 Transcription Factor Genotype Humans Infant Infant, Newborn Interferon-gamma Interleukin-4 Lipopolysaccharides Male Mice Respiratory Syncytial Viruses Respiratory Syncytial Virus Infections T-Box Domain Proteins Th2 Cells Toll-Like Receptor 4

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