High-resolution 7T MRI of the human hippocampus in vivo.

Thomas BP, Welch EB, Niederhauser BD, Whetsell WO, Anderson AW, Gore JC, Avison MJ, Creasy JL
J Magn Reson Imaging. 2008 28 (5): 1266-72

PMID: 18972336 · PMCID: PMC2669832 · DOI:10.1002/jmri.21576

PURPOSE - To describe an initial experience imaging the human hippocampus in vivo using a 7T magnetic resonance (MR) scanner and a protocol developed for very high field neuroimaging.

MATERIALS AND METHODS - Six normal subjects were scanned on a 7T whole body MR scanner equipped with a 16-channel head coil. Sequences included a full field of view T1-weighted 3D turbo field echo (T1W 3D TFE: time of acquisition (TA)=08:58), T2*-weighted 2D fast field echo (T2*W 2D FFE: TA=05:20), and susceptibility-weighted imaging (SWI: TA=04:20). SWI data were postprocessed using a minimum intensity projection (minIP) algorithm. Total imaging time was 23 minutes.

RESULTS - T1W 3D TFE images with 700 microm isotropic voxels provided excellent anatomic depiction of macroscopic hippocampal structures. T2*W 2D FFE images with 0.5 mm in-plane resolution and 2.5 mm slice thickness provided clear discrimination of the Cornu Ammonis and the compilation of adjacent sublayers of the hippocampus. SWI images (0.5 mm in-plane resolution, 1.0 mm slice thickness) delineated microvenous anatomy of the hippocampus.

CONCLUSION - In vivo 7T MR imaging can take advantage of higher signal-to-noise and novel contrast mechanisms to provide increased conspicuity of hippocampal anatomy.

Copyright (c) 2008 Wiley-Liss, Inc.

MeSH Terms (11)

Adult Algorithms Hippocampus Humans Image Enhancement Image Interpretation, Computer-Assisted Magnetic Resonance Imaging Male Middle Aged Reproducibility of Results Sensitivity and Specificity

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