Matthew Wilson
Last active: 3/24/2020

Evaluation of the alpha(2A)-adrenergic receptor gene in a heritable form of temporal lobe epilepsy.

Wilson MH, Puranam RS, Ottman R, Gilliam C, Limbird LE, George AL, McNamara JO
Neurology. 1998 51 (6): 1730-1

PMID: 9855534 · DOI:10.1212/wnl.51.6.1730

An autosomal dominant form of human temporal lobe epilepsy (TLE) has been mapped to a region of chromosome 10q that contains the intronless alpha(2A)-adrenergic receptor (alpha(2A)AR) gene. Because mutation of the alpha(2A)AR gene in the mouse fosters epileptogenesis, we developed methods for analysis of the alpha(2A)AR coding region applicable to any pathophysiologic state in which the alpha(2A)AR could be implicated in the disease mechanism. This study rules out mutations in the alpha(2A)AR coding region as causal for this form of autosomal dominant TLE.

MeSH Terms (10)

Animals Brain Chemistry Chromosomes, Human, Pair 10 DNA Primers Epilepsy, Temporal Lobe Genes, Dominant Humans Mice Mutation Receptors, Adrenergic, alpha-2

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