Gautam Bhave
Faculty Member
Last active: 8/12/2015

Volume depletion versus dehydration: how understanding the difference can guide therapy.

Bhave G, Neilson EG
Am J Kidney Dis. 2011 58 (2): 302-9

PMID: 21705120 · PMCID: PMC4096820 · DOI:10.1053/j.ajkd.2011.02.395

Although often used interchangeably, dehydration and volume depletion are not synonyms. Dehydration refers to loss of total-body water, producing hypertonicity, which now is the preferred term in lieu of dehydration, whereas volume depletion refers to a deficit in extracellular fluid volume. In particular, hypertonicity implies intracellular volume contraction, whereas volume depletion implies blood volume contraction. Using a case of hyperglycemic hypertonic nonketosis as an example, we examine the changing composition of body fluid spaces to explore the distinction between dehydration and hypertonicity from volume depletion.

Copyright © 2011 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

MeSH Terms (7)

Adult Dehydration Extracellular Fluid Fluid Therapy Humans Male Terminology as Topic

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