Raymond Hakim
Last active: 6/9/2014

Hemodialysis-associated platelet activation and thrombocytopenia.

Hakim RM, Schafer AI
Am J Med. 1985 78 (4): 575-80

PMID: 3885730 · DOI:10.1016/0002-9343(85)90398-5

The interactions between platelets and dialysis membranes were studied prospectively in 10 patients undergoing long-term stable dialysis. Transient but significant thrombocytopenia and platelet activation were found during dialysis with the commonly used cuprophane membrane. Platelet counts decreased from 231 +/- 21 X 10(3)/mm3 before dialysis to 127 +/- 28 X 10(3)/mm3 at 90 minutes following initiation of dialysis (p less than or equal to 0.007). Thromboxane B2, an index of platelet activation, also increased from a baseline level of 1.06 +/- 0.2 pg/10(6) platelets to 7.3 +/- 3.0 pg/10(6) platelets at 90 minutes (p less than or equal to 0.04). Cuprophane membranes were also shown to induce complement activation with C3a desArg, the stable derivative of C3 activation, showing a threefold increase from baseline 15 minutes after initiation of dialysis. In contrast, during dialysis with a non-complement-activating dialyzer membrane, polymethylmethacrylate, thrombocytopenia and platelet activation were not observed. These data suggest that platelet activation and thrombocytopenia during hemodialysis are associated with complement activation during hemodialysis in a manner similar to dialysis-associated neutropenia.

MeSH Terms (14)

6-Ketoprostaglandin F1 alpha Blood Platelets Cellulose Complement Activation Epoprostenol Humans Membranes, Artificial Methylmethacrylates Platelet Count Prospective Studies Renal Dialysis Thrombocytopenia Thromboxane B2 Time Factors

Connections (1)

This publication is referenced by other Labnodes entities:

Links