Raymond Hakim
Last active: 6/9/2014

Abandoning peracetic acid-based dialyzer reuse is associated with improved survival.

Lacson E, Wang W, Mooney A, Ofsthun N, Lazarus JM, Hakim RM
Clin J Am Soc Nephrol. 2011 6 (2): 297-302

PMID: 20947788 · PMCID: PMC3052219 · DOI:10.2215/CJN.03160410

BACKGROUND AND OBJECTIVES - Higher mortality risk reported with reuse versus single use of dialyzers is potentially related to reuse reagents that modify membrane surface characteristics and the blood-membrane interface. A key mechanism may involve stimulation of an inflammatory response.

DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS - In a prospective crossover design, laboratory markers and mortality from 23 hemodialysis facilities abandoning reuse with peracetic acid mixture were tracked. C-reactive protein (CRP), white blood cell (WBC) count, albumin, and prealbumin were measured for 2 consecutive months before abandoning reuse and subsequently within 3 and 6 months on single use. Survival models were utilized to compare the 6-month period before abandoning reuse (baseline) and the 6-month period on single use of dialyzers after a 3-month "washout period."

RESULTS - Patients from baseline and single-use periods had a mean age of approximately 63 years; 44% were female, 54% were diabetic, 60% were white, and the mean vintage was approximately 3.2 years. The unadjusted hazard ratio for death was 0.70 and after case-mix adjustment was 0.74 for single use compared with reuse. Patients with CRP≄5 mg/L during reuse (mean CRP=26.6 mg/ml in April) declined on single use to 20.2 mg/L by August and 20.4 mg/L by November. WBC count declined slightly during single use, but nutritional markers were unchanged.

CONCLUSIONS - Abandonment of peracetic-acid-based reuse was associated with improved survival and lower levels of inflammatory but not nutritional markers. Further study is needed to evaluate a potential link between dialyzer reuse, inflammation, and mortality.

MeSH Terms (29)

Aged Biomarkers C-Reactive Protein Cross-Over Studies Disinfectants Disposable Equipment Equipment Contamination Equipment Reuse Female Humans Inflammation Inflammation Mediators Leukocyte Count Male Materials Testing Membranes, Artificial Middle Aged North America Nutritional Status Peracetic Acid Prealbumin Prospective Studies Renal Dialysis Risk Assessment Risk Factors Survival Analysis Survival Rate Time Factors Treatment Outcome

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