Raymond Hakim
Last active: 6/9/2014

Hypertension and proteinuria: long-term sequelae of uninephrectomy in humans.

Hakim RM, Goldszer RC, Brenner BM
Kidney Int. 1984 25 (6): 930-6

PMID: 6381857 · DOI:10.1038/ki.1984.112

Renal function and blood pressure were assessed in 52 renal allograft donors 10 years or more following uninephrectomy, and their current function compared to their pre-uninephrectomy function as well as to age- and sex-matched control subjects consisting of inpatient potential renal donors and a normal "outpatient" population. The results show no significant deterioration in renal function as determined by serum creatinine or creatinine clearance, as a function of years post-uninephrectomy or age at the time of donation. A higher incidence of proteinuria and hypertension was found in male donors as compared to their pre-uninephrectomy values and to age- and sex-matched, inpatient and outpatient control subjects. Female donors had increased proteinuria when compared to pre-uninephrectomy and to age-matched, inpatient potential donors. However, the extent of proteinuria and hypertension was not significantly different from outpatient age-matched females with two kidneys. In our population, uninephrectomy is associated with mild proteinuria and hypertension.

MeSH Terms (17)

Adult Aged Creatinine Female Follow-Up Studies Glomerular Filtration Rate Humans Hypertension, Renal Kidney Transplantation Male Middle Aged Nephrectomy Postoperative Complications Proteinuria Risk Sex Factors Tissue Donors

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