Regulation of renal cortical cyclooxygenase-2 in young rats.

Zhang MZ, Wang SW, Cheng H, Zhang Y, McKanna JA, Harris RC
Am J Physiol Renal Physiol. 2003 285 (5): F881-8

PMID: 12851252 · DOI:10.1152/ajprenal.00154.2003

Cyclooxygenase-2 (COX-2) is involved in kidney morphogenesis and is transiently elevated in the immature kidney. In adult rats, renal cortical COX-2 expression is tonically suppressed by mineralocorticoids (MC) and glucocorticoids (GC) and induced by chronic salt restriction. Young rats have low levels of GC and are in a state of relative volume depletion. The present study was designed to investigate the mechanisms underlying elevated cortical COX-2 expression in the immature kidney. Supplementation of GC or MC suppressed cortical COX-2 expression in suckling rats. GC suppression was significantly, but not completely, prevented by either an MC receptor antagonist or a GC receptor antagonist. MC suppression was completely prevented by a mineralocorticoid receptor antagonist. Salt supplementation suppressed cortical COX-2 expression in a dose- and time-dependent pattern in the suckling rats. Cortical COX-2 expression in the weanling rats was upregulated by a low-salt diet and downregulated by a high-salt diet. These results suggest that relative volume depletion and reduced GC levels are involved in elevated cortical COX-2 expression in the immature rodent kidney.

MeSH Terms (15)

Aging Aldosterone Animals Animals, Newborn Animals, Suckling Corticosterone Cyclooxygenase 2 Desoxycorticosterone Isoenzymes Kidney Cortex Prostaglandin-Endoperoxide Synthases Rats Rats, Sprague-Dawley Sodium Chloride, Dietary Weaning

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