Publication

Prostaglandins in macula densa function.

Harris RC, Wang JL, Cheng HF, Zhang MZ, McKanna JA
Kidney Int Suppl. 1998 67: S49-52

PMID: 9736253 · DOI:10.1046/j.1523-1755.1998.06710.x

Cyclooxygenase (COX)-2 mRNA and immunoreactive protein localize to the macula densa and adjacent cortical thick ascending limb in renal cortex, and chronic NaCl restriction increases expression of this enzyme. These findings suggest an integral role for eicosanoids generated by macula densa-associated COX-2 in mediating renin release. As selective inhibitors of COX-2 become available, it will be important to assess their effects on the renin-angiotensin system and glomerular hemodynamics.

MeSH Terms (7)

Animals Cyclooxygenase 2 Isoenzymes Juxtaglomerular Apparatus Loop of Henle Prostaglandin-Endoperoxide Synthases Prostaglandins

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