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Telomerase, Autophagy and Acute Kidney Injury.

Harris RC, Cheng H
Nephron. 2016 134 (3): 145-148

PMID: 27376761 · PMCID: PMC5547439 · DOI:10.1159/000446665

In humans, aging is associated with telomere shortening and increased susceptibility to acute kidney injury. Telomerase is essential to maintain telomere length. The fourth generation mice with telomerase deletion have progressive shortening of telomeres. Those mice delayed recovery from ischemia-reperfusion injury, due to an increase in tubule cell senescence and impairment of autophagy, the latter of which may be mediated in part by increased mTOR signaling. © 2016 S. Karger AG, Basel.

MeSH Terms (5)

Acute Kidney Injury Autophagy Humans Telomerase Telomere

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