Macula densa sensing and signaling mechanisms of renin release.

Peti-Peterdi J, Harris RC
J Am Soc Nephrol. 2010 21 (7): 1093-6

PMID: 20360309 · PMCID: PMC4577295 · DOI:10.1681/ASN.2009070759

Macula densa cells in the distal nephron, according to the classic paradigm, are salt sensors that generate paracrine chemical signals in the juxtaglomerular apparatus to control vital kidney functions, including renal blood flow, glomerular filtration, and renin release. Renin is the rate-limiting step in the activation of the renin-angiotensin system, a key modulator of body fluid homeostasis. Here, we discuss recent advances in understanding macula densa sensing and suggest these cells, in addition to salt, also sense various chemical and metabolic signals in the tubular environment that directly trigger renin release.

MeSH Terms (14)

Animals Glomerular Filtration Rate Homeostasis Humans Juxtaglomerular Apparatus Kidney Tubules, Distal Mice Mice, Knockout Models, Animal Nephrons Regional Blood Flow Renin Renin-Angiotensin System Signal Transduction

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