Does cyclooxygenase-2 affect blood pressure?

Cheng HF, Harris RC
Curr Hypertens Rep. 2003 5 (1): 87-92

PMID: 12530941 · DOI:10.1007/s11906-003-0016-y

With the development and clinical implementation of the new cyclooxygenase (COX)-2 inhibitors, their safety, including the effects on renal function and blood pressure, is attracting increasing attention. In the kidney, COX-2 is constitutively expressed and is highly regulated in response to alterations in intravascular volume. COX-2 metabolites have been implicated in mediation of renin release, regulation of sodium excretion, and maintenance of renal blood flow. Similar to conventional nonsteroidal anti-inflammatory drugs, inhibition of COX-2 may cause modest elevations in blood pressure in a minority of subjects. COX-2 inhibitors may also exacerbate pre-existing hypertension or interfere with other antihypertensive drugs. Special caution should be taken in patients with volume depletion or decreased organ perfusion.

MeSH Terms (14)

Blood Pressure Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors Glomerular Filtration Rate Humans Hypertension Isoenzymes Kidney Membrane Proteins Prostaglandin-Endoperoxide Synthases Renal Circulation Renin-Angiotensin System Sodium

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