Matthew Robson
Research Fellow
Last active: 10/19/2015

Sigma receptors: potential targets for a new class of antidepressant drug.

Fishback JA, Robson MJ, Xu YT, Matsumoto RR
Pharmacol Ther. 2010 127 (3): 271-82

PMID: 20438757 · PMCID: PMC3993947 · DOI:10.1016/j.pharmthera.2010.04.003

Despite the widespread and devastating impact of depression on society, our current understanding of its pathogenesis is limited. Likewise, existing treatments are inadequate, providing relief to only a subset of people suffering from depression. The search for more effective antidepressant drugs includes the investigation of new molecular targets. Among them, current data suggests that sigma receptors are involved in multiple processes effecting antidepressant-like actions in vivo and in vitro. This review summarizes accumulated evidence supporting a role for sigma receptors in antidepressant effects and provides a conceptual framework for delineating their potential roles over the course of antidepressant treatment.

2010 Elsevier Inc. All rights reserved.

MeSH Terms (8)

Animals Antidepressive Agents Depression Drug Design Humans Receptors, Neurotransmitter Receptors, sigma Signal Transduction

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