Borden Lacy
Last active: 3/24/2020

Unraveling the structures and modes of action of bacterial toxins.

Lacy DB, Stevens RC
Curr Opin Struct Biol. 1998 8 (6): 778-84

PMID: 9914258 · DOI:10.1016/s0959-440x(98)80098-5

The mechanism by which a soluble protein converts into a protein that spans a membrane remains a central question in understanding the molecular mechanism of toxicity of bacterial protein toxins. Using crystallographic structures of soluble toxins as templates, the past year has seen a number of experiments that are designed to probe the membrane state using other structural methods. In addition, crystallographic information concerning the clostridial neurotoxins has emerged, suggesting a novel mechanism of pore formation and new relationships between toxin binding domains.

MeSH Terms (6)

Bacterial Toxins Models, Molecular Protein Binding Protein Conformation Receptors, Cell Surface Structure-Activity Relationship

Connections (1)

This publication is referenced by other Labnodes entities: