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Matthew Tyska
Faculty Member
Last active: 4/10/2018

Ready…aim…fire into the lumen: a new role for enterocyte microvilli in gut host defense.

Shifrin DA, Tyska MJ
Gut Microbes. 2012 3 (5): 460-2

PMID: 22825496 · PMCID: PMC3466500 · DOI:10.4161/gmic.21247

Recent studies from our laboratory revealed that enterocyte brush border microvilli release small vesicles laden with host defense machinery into the intestinal lumen. In this addendum, we introduce a multi-faceted model for the function of these lumenal vesicles in the gut; we also consider some of the important unanswered questions that must be addressed in order to develop our understanding of this novel aspect of innate intestinal immunity.

MeSH Terms (8)

Animals Enterocytes Gastrointestinal Tract Humans Immunity, Innate Microvilli Models, Biological Secretory Vesicles

Connections (2)

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