jeff franklin
Faculty Member
Last active: 3/28/2016

Mtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineage in the small intestine.

Amann JM, Chyla BJ, Ellis TC, Martinez A, Moore AC, Franklin JL, McGhee L, Meyers S, Ohm JE, Luce KS, Ouelette AJ, Washington MK, Thompson MA, King D, Gautam S, Coffey RJ, Whitehead RH, Hiebert SW
Mol Cell Biol. 2005 25 (21): 9576-85

PMID: 16227606 · PMCID: PMC1265807 · DOI:10.1128/MCB.25.21.9576-9585.2005

Two members of the MTG/ETO family of transcriptional corepressors, MTG8 and MTG16, are disrupted by chromosomal translocations in up to 15% of acute myeloid leukemia cases. The third family member, MTGR1, was identified as a factor that associates with the t(8;21) fusion protein RUNX1-MTG8. We demonstrate that Mtgr1 associates with mSin3A, N-CoR, and histone deacetylase 3 and that when tethered to DNA, Mtgr1 represses transcription, suggesting that Mtgr1 also acts as a transcriptional corepressor. To define the biological function of Mtgr1, we created Mtgr1-null mice. These mice are proportionally smaller than their littermates during embryogenesis and throughout their life span but otherwise develop normally. However, these mice display a progressive reduction in the secretory epithelial cell lineage in the small intestine. This is not due to the loss of small intestinal progenitor cells expressing Gfi1, which is required for the formation of goblet and Paneth cells, implying that loss of Mtgr1 impairs the maturation of secretory cells in the small intestine.

MeSH Terms (18)

Animals Cell Line Cell Lineage Chlorocebus aethiops Enteroendocrine Cells Goblet Cells Histone Deacetylases Humans Intestine, Small Mice Nuclear Proteins Nuclear Receptor Co-Repressor 1 Paneth Cells Phosphoproteins Protein Binding Repressor Proteins Sin3 Histone Deacetylase and Corepressor Complex Transcription, Genetic

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