Claudia Andl
Faculty Member
Last active: 10/13/2015

CD44 upregulation in E-cadherin-negative esophageal cancers results in cell invasion.

Le Bras GF, Allison GL, Richards NF, Ansari SS, Washington MK, Andl CD
PLoS One. 2011 6 (11): e27063

PMID: 22069487 · PMCID: PMC3206075 · DOI:10.1371/journal.pone.0027063

E-cadherin is frequently lost during epithelial-mesenchymal transition and the progression of epithelial tumorigenesis. We found a marker of epithelial-mesenchymal transition, CD44, upregulated in response to functional loss of E-cadherin in esophageal cell lines and cancer. Loss of E-cadherin expression correlates with increased expression of CD44 standard isoform. Using an organotypic reconstruct model, we show increased CD44 expression in areas of cell invasion is associated with MMP-9 at the leading edge. Moreover, Activin A increases cell invasion through CD44 upregulation after E-cadherin loss. Taken together, our results provide functional evidence of CD44 upregulation in esophageal cancer invasion.

MeSH Terms (17)

Blotting, Western Cadherins Cell Adhesion Cell Line Cell Movement Cell Proliferation Epithelial Cells Esophageal Neoplasms Esophagus Fluorescent Antibody Technique Gene Expression Regulation, Neoplastic Humans Hyaluronan Receptors Immunoenzyme Techniques Matrix Metalloproteinase 9 Neoplasm Invasiveness Up-Regulation

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