Thomas Andl
Faculty Member
Last active: 3/20/2014

The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles.

Andl T, Murchison EP, Liu F, Zhang Y, Yunta-Gonzalez M, Tobias JW, Andl CD, Seykora JT, Hannon GJ, Millar SE
Curr Biol. 2006 16 (10): 1041-9

PMID: 16682203 · PMCID: PMC2996092 · DOI:10.1016/j.cub.2006.04.005

The discovery that microRNAs (miRNAs) play important roles in regulating gene expression via posttranscriptional repression has revealed a previously unsuspected mechanism controlling development and progenitor-cell function (reviewed in ); however, little is known of miRNA functions in mammalian organogenesis. Processing of miRNAs and their assembly into the RNA-induced silencing (RISC) complex requires the essential multifunctional enzyme Dicer . We found that Dicer mRNA and multiple miRNAs are expressed in mouse skin, suggesting roles in skin- and hair-follicle biology. In newborn mice carrying an epidermal-specific Dicer deletion, hair follicles were stunted and hypoproliferative. Hair-shaft and inner-root-sheath differentiation was initiated, but the mutant hair follicles were misoriented and expression of the key signaling molecules Shh and Notch1 was lost by postnatal day 7. At this stage, hair-follicle dermal papillae were observed to evaginate, forming highly unusual structures within the basal epidermis. Normal hair shafts were not produced in the Dicer mutant, and the follicles lacked stem cell markers and degenerated. In contrast to decreased follicular proliferation, the epidermis became hyperproliferative. These results reveal critical roles for Dicer in the skin and implicate miRNAs in key aspects of epidermal and hair-follicle development and function.

MeSH Terms (18)

Animals Hair Hair Follicle Hedgehog Proteins Keratin-15 Keratins Mice MicroRNAs Morphogenesis Oncogene Proteins Receptor, Notch1 Ribonuclease III Sequence Deletion Skin Skin Abnormalities Stem Cells Trans-Activators Zinc Finger Protein GLI1

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