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Oncogenic KRAS promotes malignant brain tumors in zebrafish.

Ju B, Chen W, Orr BA, Spitsbergen JM, Jia S, Eden CJ, Henson HE, Taylor MR
Mol Cancer. 2015 14: 18

PMID: 25644510 · PMCID: PMC4320811 · DOI:10.1186/s12943-015-0288-2

Zebrafish have been used as a vertebrate model to study human cancers such as melanoma, rhabdomyosarcoma, liver cancer, and leukemia as well as for high-throughput screening of small molecules of therapeutic value. However, they are just emerging as a model for human brain tumors, which are among the most devastating and difficult to treat. In this study, we evaluated zebrafish as a brain tumor model by overexpressing a human version of oncogenic KRAS (KRAS(G12V)).

MeSH Terms (20)

Animals Animals, Genetically Modified Brain Brain Neoplasms Cell Transformation, Neoplastic Disease Models, Animal Drug Screening Assays, Antitumor Gene Expression Humans Immunohistochemistry Keratin-5 Nerve Tissue Proteins Promoter Regions, Genetic Proto-Oncogene Proteins Proto-Oncogene Proteins p21(ras) ras Proteins Signal Transduction TOR Serine-Threonine Kinases Transgenes Zebrafish

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