Ju B, Chen W, Orr BA, Spitsbergen JM, Jia S, Eden CJ, Henson HE, Taylor MR
Mol Cancer. 2015 14
· PMCID: PMC4320811
Zebrafish have been used as a vertebrate model to study human cancers such as melanoma, rhabdomyosarcoma, liver cancer, and leukemia as well as for high-throughput screening of small molecules of therapeutic value. However, they are just emerging as a model for human brain tumors, which are among the most devastating and difficult to treat. In this study, we evaluated zebrafish as a brain tumor model by overexpressing a human version of oncogenic KRAS (KRAS(G12V)).
MeSH Terms (20)Animals Animals, Genetically Modified Brain Brain Neoplasms Cell Transformation, Neoplastic Disease Models, Animal Drug Screening Assays, Antitumor Gene Expression Humans Immunohistochemistry Keratin-5 Nerve Tissue Proteins Promoter Regions, Genetic Proto-Oncogene Proteins Proto-Oncogene Proteins p21(ras) ras Proteins Signal Transduction TOR Serine-Threonine Kinases Transgenes Zebrafish