Jeffrey Smith
Faculty Member
Last active: 3/14/2018

Genetic variation and coronary atherosclerosis in patients with systemic lupus erythematosus.

Chung CP, Solus JF, Oeser A, Li C, Raggi P, Smith JR, Stein CM
Lupus. 2014 23 (9): 876-80

PMID: 24699314 · PMCID: PMC4185017 · DOI:10.1177/0961203314530019

Coronary artery disease is the major cause of mortality in patients with systemic lupus erythematosus (SLE). Increased cardiovascular risk in SLE is not explained by traditional risk factors. We examined the hypothesis that genetic variation contributes to the presence of coronary atherosclerosis in patients with SLE. The genotypes of single-nucleotide polymorphisms (SNP) in 152 candidate genes linked with autoimmune or cardiovascular risk were determined in 125 patients with SLE. Coronary artery calcium (CAC), a measure of coronary atherosclerosis, was detected in 32 patients (26%) by electron-beam computed tomography. Polymorphism in 20 of the candidate genes (ADAM33, ADIPOQ, CCL5, CCR7, CDKN2B, CSF1, IL4, IL12A, IL23R, INS, IRF5, MIF, MS4A1, PTGS1, PTPN22, RETN, SELE, TNFSF4, TNFRSF11B, and VCAM1) were nominally associated with the presence of CAC (p-values = 0.001-0.047 after adjustment for age, sex and race). Some of these are known susceptibility genes for SLE and others have been implicated in cardiovascular disease in other populations. No association withstood false discovery rate adjustment. Replication studies in additional cohorts of patients with SLE may be informative.

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MeSH Terms (9)

Adult Coronary Artery Disease Female Genetic Variation Humans Lupus Erythematosus, Systemic Male Polymorphism, Single Nucleotide Risk Factors

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