James Crowe
Faculty Member
Last active: 3/31/2019

Use of Human Hybridoma Technology To Isolate Human Monoclonal Antibodies.

Smith SA, Crowe JE
Microbiol Spectr. 2015 3 (1): AID-0027-2014

PMID: 26104564 · DOI:10.1128/microbiolspec.AID-0027-2014

The human hybridoma technique offers an important approach for isolation of human monoclonal antibodies. A diversity of approaches can be used with varying success. Recent technical advances in expanding the starting number of human antigen-specific B cells, improving fusion efficiency, and isolating new myeloma partners and new cell cloning methods have enabled the development of protocols that make the isolation of human monoclonal antibodies from blood samples feasible. Undoubtedly, additional innovations that could improve efficiency are possible.

MeSH Terms (7)

Antibodies, Monoclonal Antigens B-Lymphocytes Biotechnology Cell Fusion Humans Hybridomas

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