James Crowe
Faculty Member
Last active: 3/31/2019

Regulatory T cell expression of CLA or α(4)β(7) and skin or gut acute GVHD outcomes.

Engelhardt BG, Jagasia M, Savani BN, Bratcher NL, Greer JP, Jiang A, Kassim AA, Lu P, Schuening F, Yoder SM, Rock MT, Crowe JE
Bone Marrow Transplant. 2011 46 (3): 436-42

PMID: 20577222 · PMCID: PMC3217583 · DOI:10.1038/bmt.2010.127

Regulatory T cells (Tregs) are a suppressive subset of CD4(+) T lymphocytes implicated in the prevention of acute GVHD (aGVHD) after allo-SCT (ASCT). To determine whether increased frequency of Tregs with a skin-homing (cutaneous lymphocyte Ag, CLA(+)) or a gut-homing (α(4)β(7)(+)) phenotype is associated with reduced risk of skin or gut aGVHD, respectively, we quantified circulating CLA(+) or α(4)β(7)(+) on Tregs at the time of neutrophil engraftment in 43 patients undergoing ASCT. Increased CLA(+) Tregs at engraftment was associated with the prevention of skin aGVHD (2.6 vs 1.7%; P=0.038 (no skin aGVHD vs skin aGVHD)), and increased frequencies of CLA(+) and α(4)β(7)(+) Tregs were negatively correlated with severity of skin aGVHD (odds ratio (OR), 0.67; 95% confidence interval (CI), 0.46-0.98; P=0.041) or gut aGVHD (OR, 0.93; 95% CI, 0.88-0.99; P=0.031), respectively. This initial report suggests that Treg tissue-homing subsets help to regulate organ-specific risk and severity of aGVHD after human ASCT. These results need to be validated in a larger, multicenter cohort.

MeSH Terms (18)

Acute Disease Adult Aged Antigens, Differentiation, T-Lymphocyte Cohort Studies Cytokines Female Graft vs Host Disease Humans Immunophenotyping Integrins Intestinal Diseases Male Membrane Glycoproteins Middle Aged Skin Diseases T-Lymphocytes, Regulatory Young Adult

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