James Crowe
Faculty Member
Last active: 3/31/2019

Naturally occurring human monoclonal antibodies neutralize both 1918 and 2009 pandemic influenza A (H1N1) viruses.

Krause JC, Tumpey TM, Huffman CJ, McGraw PA, Pearce MB, Tsibane T, Hai R, Basler CF, Crowe JE
J Virol. 2010 84 (6): 3127-30

PMID: 20042511 · PMCID: PMC2826039 · DOI:10.1128/JVI.02184-09

The 2009 pandemic influenza A (H1N1) virus exhibits hemagglutinin protein sequence homology with the 1918 pandemic influenza virus. We found that human monoclonal antibodies recognized the Sa antigenic site on the head domains of both 1918 and 2009 hemagglutinins, a site that is hypervariable due to immune selection. These antibodies exhibited high potency against the 2009 virus in vitro, and one exerted a marked therapeutic effect in vivo.

MeSH Terms (16)

Amino Acid Sequence Animals Antibodies, Monoclonal Antibodies, Neutralizing Antigens, Viral Cell Line Disease Outbreaks Hemagglutinin Glycoproteins, Influenza Virus Humans Influenza, Human Influenza A Virus, H1N1 Subtype Molecular Sequence Data Neutralization Tests Orthomyxoviridae Infections Sequence Alignment Swine

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