James Crowe
Faculty Member
Last active: 3/31/2019

Coronavirus infection and hospitalizations for acute respiratory illness in young children.

Talbot HK, Crowe JE, Edwards KM, Griffin MR, Zhu Y, Weinberg GA, Szilagyi PG, Hall CB, Podsiad AB, Iwane M, Williams JV, New Vaccine Surveillance Network
J Med Virol. 2009 81 (5): 853-6

PMID: 19319948 · PMCID: PMC2767383 · DOI:10.1002/jmv.21443

There is only limited knowledge on the burden of disease due to both new (HCoV-NL63 and HKU-1) and previously discovered coronaviruses (OC43 and 229E) in children. Respiratory specimens and clinical data were prospectively collected in an active, population-based surveillance study over a 2-year period from children aged <5 years hospitalized with acute respiratory symptoms or fever. These samples were retrospectively tested by real-time RT-PCR for HCoV-NL63, HKU1, OC43, and 229E. Human coronaviruses (HCoVs) were identified in 2.2% of study children <2 years of age. Rates of HCoV-associated hospitalization per 10,000 were 10.2 (95% CI 4.3, 17.6), 4.2 (95% CI 1.9, 6.9), and 0 (95% CI 0, 3.7) in children aged <6 months, 6-23 months, and 24-59 months, respectively. Coronaviruses were identified in a modest number of hospitalized children.

Copyright 2009 Wiley-Liss, Inc.

MeSH Terms (16)

Acute Disease Child, Preschool Coronavirus Coronavirus 229E, Human Coronavirus Infections Coronavirus OC43, Human Female Hospitalization Humans Incidence Infant Infant, Newborn Male Population Surveillance Respiratory System Respiratory Tract Infections

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