James Crowe
Faculty Member
Last active: 3/31/2019

A prospective study comparing human metapneumovirus with other respiratory viruses in adults with hematologic malignancies and respiratory tract infections.

Williams JV, Martino R, Rabella N, Otegui M, Parody R, Heck JM, Crowe JE
J Infect Dis. 2005 192 (6): 1061-5

PMID: 16107960 · PMCID: PMC1483060 · DOI:10.1086/432732

Human metapneumovirus (hMPV) is a recently described paramyxovirus associated with upper and lower respiratory-tract infection (URI and LRI, respectively). We conducted a prospective study of URI and LRI in adults with hematologic malignancies during a 4-year period. We retrospectively tested samples by reverse-transcription polymerase chain reaction for hMPV and analyzed clinical data. Twenty-two (9%) of 251 episodes of respiratory infection tested positive for hMPV. Sixteen (73%) of the illnesses occurred in hematopoietic stem-cell transplant recipients. Nine patients with hMPV developed LRI; 3 of these patients died. hMPV is a common cause of respiratory infections in adults with hematologic malignancies, with associated morbidity and mortality.

MeSH Terms (12)

Adult Aged Female Hematologic Neoplasms Hematopoietic Stem Cell Transplantation Humans Male Metapneumovirus Middle Aged Paramyxoviridae Infections Prospective Studies Respiratory Tract Infections

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