James Crowe
Faculty Member
Last active: 3/31/2020

Molecular mechanisms driving respiratory syncytial virus assembly.

Shaikh FY, Crowe JE
Future Microbiol. 2013 8 (1): 123-31

PMID: 23252497 · PMCID: PMC3577052 · DOI:10.2217/fmb.12.132

Respiratory syncytial virus is a single-stranded RNA virus in the Paramyxoviridae family that preferentially assembles and buds from the apical surface of polarized epithelial cells, forming filamentous structures that contain both viral proteins and the genomic RNA. Recent studies have described both viral and host factors that are involved in ribonucleoprotein assembly and trafficking of viral proteins to the cell surface. At the cell surface, viral proteins assemble into filaments that probably require interactions between viral proteins, host proteins and the cell membrane. Finally, a membrane scission event must occur to release the free virion. This article will review the recent literature describing the mechanisms that drive respiratory syncytial virus assembly and budding.

MeSH Terms (12)

Animals Cell Membrane Cytoskeleton Host-Pathogen Interactions Humans Protein Transport Respiratory Syncytial Viruses Ribonucleoproteins Viral Fusion Proteins Viral Proteins Virus Assembly Virus Release

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