James Crowe
Faculty Member
Last active: 3/31/2020

Recent advances in the study of human antibody responses to influenza virus using optimized human hybridoma approaches.

Crowe JE
Vaccine. 2009 27 Suppl 6: G47-51

PMID: 20006140 · PMCID: PMC2835990 · DOI:10.1016/j.vaccine.2009.10.124

Influenza viruses exhibit a fascinating level of antigenic heterogeneity that facilitates re-infection in the human population. The human antibody repertoire also manifests endless capability for variation in the genes that specify the portion of antibody molecules interacting with epitopes. A recent explosion of techniques for isolating human monoclonal antibodies to viruses has led to isolation of new antibodies that allow glimpses into the molecular basis for recognition and escape that underlies the constant antigenic drift in influenza surface proteins. These studies also reveal evidence for lifelong persistence of immunity to some influenza viruses.

MeSH Terms (9)

Antibodies, Monoclonal Antibodies, Viral Antibody Formation Antigens, Viral Epitopes Humans Hybridomas Influenza, Human Orthomyxoviridae

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