James Crowe
Faculty Member
Last active: 3/31/2020

Prevalence of reovirus-specific antibodies in young children in Nashville, Tennessee.

Tai JH, Williams JV, Edwards KM, Wright PF, Crowe JE, Dermody TS
J Infect Dis. 2005 191 (8): 1221-4

PMID: 15776366 · PMCID: PMC7109872 · DOI:10.1086/428911

Although reovirus infections are thought to be common in adults, there have been few assessments of the seroprevalence of reovirus in young children. We developed an indirect enzyme-linked immunosorbent assay to measure levels of total antireovirus immunoglobulin A, G, and M in serum specimens collected from otherwise healthy infants and children (1 month to 5 years of age) in Nashville, Tennessee. Of the 272 serum specimens evaluated, 64 (23.5%) tested positive for reovirus-specific antibodies. We observed an age-dependent increase in reovirus-specific antibodies in children 1 year of age and older, peaking at 50.0% in children 5-6 years of age. These findings suggest that reovirus infections are common during early childhood.

MeSH Terms (14)

Age Distribution Aging Antibodies, Viral Antibody Specificity Child, Preschool Enzyme-Linked Immunosorbent Assay Female Humans Infant Infant, Newborn Male Orthoreovirus, Mammalian Reoviridae Infections Tennessee

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