Daniel Liebler
Faculty Member
Last active: 2/15/2016

Safety assessment of alkyl benzoates as used in cosmetics.

'Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler D, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA
Int J Toxicol. 2012 31 (6 Suppl): 342S-72S

PMID: 23283706 · DOI:10.1177/1091581812467379

The functions of alkyl benzoates in cosmetics include fragrance ingredients, skin-conditioning agents--emollient, skin-conditioning agents--miscellaneous, preservatives, solvents, and plasticizers. The Cosmetic Ingredient Review Expert Panel reviewed the relevant animal and human data and noted gaps in the available safety data for some of the alkyl benzoates. Similar structure activity relationships, biologic functions, and cosmetic product usage allowed the available data of many of the alkyl benzoates to be extended to the entire group. Carcinogenicity data were not available, but available data indicated that these alkyl benzoate cosmetic ingredients are not genotoxic. Also benzoic acid and tested component alcohols were not reproductive or developmental toxicants, are not genotoxic in almost all assays, and are not carcinogenic. These ingredients were determined to be safe in the present practices of use and concentration.

MeSH Terms (9)

Animals Benzoates Consumer Product Safety Cosmetics Humans Risk Assessment Structure-Activity Relationship Surface-Active Agents Toxicity Tests

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